RESEARCH RESULTS

研究業績

2024年　教室業績
  1. Kawashima Y, Hata M, Miyake M, Kusaka M, Oishi A, Ooto S, Tamura H, Miyata M, Uji A, Ueda-Arakawa N, Takahashi A, Tsujikawa A. MACULAR CHORIORETINAL ATROPHY AND VISUAL OUTCOMES IN RANIBIZUMAB- OR AFLIBERCEPT-TREATED MYOPIC CHOROIDAL NEOVASCULARIZATION. Retina. 2024 Jan 1;44(1):127-135.
  2. Miyata M, Kido A, Miyake M, Tamura H, Kamei T, Wada S, Ueshima H, Kawai K, Nakao S, Yamamoto A, Suda K, Nakano E, Tagawa M, Tsujikawa A. Prevalence and Incidence of Strabismus by Age Group in Japan: A Nationwide Population-Based Cohort Study. Am J Ophthalmol. 2024 Jun;262:222-228.
  3. Kogo T, Muraoka Y, Ishikura M, Nishigori N, Akiyama Y, Ueda-Arakawa N, Miyata M, Ooto S, Hata M, Takahashi A, Miyake M, Tsujikawa A. Pigment Epithelial Detachment and Leak Point Locations in Central Serous Chorioretinopathy. Am J Ophthalmol. 2024 May;261:19-27.
  4. Ueda Y, Suda K, Kameda T, Ikeda HO, Miyake M, Hasegawa T, Numa S, Tsujikawa A. Risk Factors for Progression of Primary Open-Angle Glaucoma with Lower Normal Intraocular Pressure. Ophthalmic Res. 2024;67(1):184-191. 
  5. Nagasaki T, Miyake M, Sato S, Murase K, Kawaguchi T, Matsumoto T, Nakatsuka Y, Mori Y, Ikeda HO, Sunadome H, Hamada S, Takahashi N, Togawa J, Kanai O, Uiji S, Wakamura T, Tabara Y, Tsujikawa A, Matsuda F, Hirai T, Chin K; Nagahama Study Group Executive Committee members. Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study. Ann Am Thorac Soc. 2024 Apr;21(4):644-650.
  6. Kanzaki Y, Matoba R, Ishihara K, Morita T, Muraoka Y, Kimura S, Koto T, Kawasaki R, Baba T, Okamoto F, Inoue M, Sakamoto T, Tsujikawa A, Morizane Y. Japan-epiretinal membrane (J-ERM) registry: A prospective cohort study protocol investigating the surgical outcome of epiretinal membrane. PLoS One. 2024 Feb 8;19(2):e0297347.
  7. Akiyama Y, Muraoka Y, Kogo T, Nishigori N, Ishikura M, Ishihara K, Murakami T, Ooto S, Tsujikawa A. Vitreous hemorrhage in retinal vein occlusion without visible traction from the posterior vitreous membrane: An optical coherence tomography angiography case report study. Heliyon. 2024 Feb 10;10(4):e26019.
  8. Tanaka A, Hata M, Tsuchikawa M, Ueda-Arakawa N, Tamura H, Miyata M, Takahashi A, Kido A, Muraoka Y, Miyake M, Ooto S, Tsujikawa A. Short-Term Outcomes of 3 Monthly intravitreal Faricimab On Different Subtypes of Neovascular Age-Related Macular Degeneration. Clin Ophthalmol. 2024 Feb 20;18:507-516.
  9. Ueno Y, Oda M, Yamaguchi T, Fukuoka H, Nejima R, Kitaguchi Y, Miyake M, Akiyama M, Miyata K, Kashiwagi K, Maeda N, Shimazaki J, Noma H, Mori K, Oshika T. Deep learning model for extensive smartphone-based diagnosis and triage of cataracts and multiple corneal diseases. Br J Ophthalmol. 2024 Sep 20;108(10):1406-1413.
  10. Wong WM, Tham YC, Simunovic MP, Chen FK, Luu CD, Chen H, Jin ZB, Shen RJ, Li S, Sui R, Zhao C, Yang L, Bhende M, Raman R, Sen P, Ghosh A, Poornachandra B, Sasongko MB, Arianti A, Chia V, Mangunsong CO, Manurung F, Fujinami K, Ikeda H, Woo SJ, Kim SJ, Mohd Khialdin S, Othman O, Bastion MC, Kamalden AT, Lott PWP, Fong K, Shunmugam M, Lim A, Thapa R, Pradhan E, Rajkarnikar SP, Adhikari S, Ibañez BMBI, Koh A, Chan CMM, Fenner BJ, Tan TE, Laude A, Ngo WK, Holder GE, Su X, Chen TC, Wang NK, Kang EY, Huang CH, Surawatsatien N, Pisuchpen P, Sujirakul T, Kumaramanickavel G, Singh M, Leroy B, Michaelides M, Cheng CY, Chen LJ, Chan HW. Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases. Asia Pac J Ophthalmol (Phila). 2024 Jan-Feb;13(1):100030. 
  11. Murakami T, Gardner TW. Rejuvenation of diabetic macular edema with senolytic therapy. Nat Med. 2024 Feb;30(2):346-347.
  12. Yamamoto A, Miyata M, Tsujikawa A. Ophthalmologists' assessment of the handling characteristics of the novel Finesse Reflex Handle in comparison to those of a conventional handle. Sci Rep. 2024 Mar 8;14(1):5736.
  13. Higashi T, Goto T, Onodera R, Hirotsu T, Ikeda HO, Motoyama K. Sustained Release Formulation of Hydroxypropyl-β-cyclodextrin Eye Drops Using Xanthan Gum. Chem Pharm Bull (Tokyo). 2024;72(4):381-384.
  14. Kogo T, Muraoka Y, Ishikura M, Nishigori N, Akiyama Y, Hata M, Tsujikawa A. Structural changes in laser-induced retinopathy examined by adaptive optics optical coherence tomography. Am J Ophthalmol Case Rep. 2024 Apr 10;34:102052.
  15. Otsuka Y, Imamura K, Oishi A, Asakawa K, Kondo T, Nakai R, Suga M, Inoue I, Sagara Y, Tsukita K, Teranaka K, Nishimura Y, Watanabe A, Umeyama K, Okushima N, Mitani K, Nagashima H, Kawakami K, Muguruma K, Tsujikawa A, Inoue H. Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction. JCI Insight. 2024 Apr 22;9(8):e174179.
  16. Akada M, Muraoka Y, Morooka S, Ishihara K, Kogo T, Akaike N, Nakanishi K, Yamao Y, Hata M, Tsujikawa A. Blood flow alterations in cavernous sinus dural arteriovenous fistula: Optical coherence tomography angiography findings. Am J Ophthalmol Case Rep. 2024 May 3;34:102066.
  17. Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results. Nat Med. 2024 Feb;30(2):443-454.
  18. Onishi Y, Shimizu H, Koyasu S, Taura D, Takahashi A, Uza N, Isoda H, Nakamoto Y. Association Between Pancreatic Cysts and Diabetes Mellitus in Von Hippel- Lindau Disease. Cureus. 2024 Feb 23;16(2):e54781.
  19. Lee JJ, Ishihara K, Notomi S, Efstathiou NE, Ueta T, Maidana D, Chen X, Iesato Y, Caligiana A, Vavvas DG. Corrigendum to "Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells" [Biochem. Biophys. Res. Commun. 521 (2) 414-419]. Biochem Biophys Res Commun. 2024 Jun 18;712-713:149930. Epub 2024 Apr 16. Erratum for: Biochem Biophys Res Commun. 2020 Jan 8;521(2):414-419.
  20. Sato Y, Ueda-Arakawa N, Takahashi A, Miyake M, Mori Y, Miyara Y, Hara C, Kitajima Y, Maruko R, Kawai M, Takahashi H, Koizumi H, Maruyama-Inoue M, Yanagi Y, Iida T, Takahashi K, Sakamoto T, Tsujikawa A. Clinical Characteristics and Progression of Pachychoroid and Conventional Geographic Atrophy. Ophthalmol Sci. 2024 Apr 10;4(5):100528.
  21. Honda Y, Miyata M, Miyake M, Hata M, Numa S, Mori Y, Ooto S, Tamura H, Ueda- Arakawa N, Muraoka Y, Takahashi A, Sado K, Kido A, Tsujikawa A. Differences between pathologic and non-pathologic high myopia in 4-year outcomes of anti- VEGF therapy for macular neovascularization. Sci Rep. 2024 Jun 11;14(1):13399.
  22. Koizumi H, Gomi F, Tsujikawa A, Honda S, Mori R, Ochi H, Iwasaki K, Okada AA; TENAYA and LUCERNE Investigators. Efficacy, durability, and safety of faricimab up to every 16 weeks in patients with neovascular age-related macular degeneration: 2-year results from the Japan subgroup of the phase III TENAYA trial. Graefes Arch Clin Exp Ophthalmol. 2024 Aug;262(8):2439-2448.
  23. Ishikura M, Muraoka Y, Nishigori N, Kogo T, Akiyama Y, Numa S, Hata M, Ishihara K, Ooto S, Tsujikawa A. Cellular Determinants of Visual Outcomes in Eyes with Epiretinal Membrane: Insights from Adaptive Optics OCT. Ophthalmol Sci. 2024 Apr 22;4(5):100536.
  24. Akiyama Y, Muraoka Y, Kogo T, Hata M, Tsujikawa A. Multimodal chorioretinal imaging in Wyburn-Mason syndrome: A case report. Heliyon. 2024 Jul 20;10(14):e34872.
  25. Ikeda HO, Hasegawa T, Abe H, Amino Y, Nakagawa T, Tada H, Miyata M, Oishi A, Morita S, Tsujikawa A. Efficacy and Safety of Branched Chain Amino Acids on Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Transl Vis Sci Technol. 2024 Aug 1;13(8):29.
  26. Ishikura M, Muraoka Y, Hirami Y, Tu HY, Mandai M. Adaptive Optics Optical Coherence Tomography Analysis of Induced Pluripotent Stem Cell-Derived Retinal Organoid Transplantation in Retinitis Pigmentosa. Cureus. 2024 Jul 19;16(7):e64962.
  27. Tsuda K, Miyata M, Kawai K, Nakao S, Yamamoto A, Suda K, Nakano E, Tagawa M, Muraoka Y, Sakata R, Tsujikawa A. Relationship between binocular vision and Govetto's stage in monocular idiopathic epiretinal membrane. Sci Rep. 2024 Sep 3;14(1):20442.
  28. Miyake M, Mori Y, Wada S, Yamada K, Shiraishi R, Numa S, Suda K, Kameda T, Ikeda H, Akagi T, Aibara T, Tamura H, Tsujikawa A. Comparison of a Novel Head- Mounted Objective Auto-perimetry (Gaze Analyzing Perimeter) and Humphrey Field Analyzer. Ophthalmol Glaucoma. 2024 Sep-Oct;7(5):445-453.
  29. Wong WM, Tham YC, Ayton LN, Britten-Jones AC, Edwards TL, Grigg J, Simunovic MP, Chen FK, Jin ZB, Shen RJ, Sui R, Yang L, Zhao C, Chen H, Li S, Ding X, Bhende M, Raman R, Sen P, Poornachandra B, Chia V, Manurung F, Sasongko MB, Ikeda H, Fujinami K, Woo SJ, Kim SJ, Bastion MC, Kamalden AT, Lott PP, Fong K, Shunmugam M, Lim A, Thapa R, Ibañez BMB, Koh A, Holder GE, Su X, Chan CM, Fenner BJ, Laude A, Ngo WK, Chen TC, Wang NK, Kang EY, Surawatsatien N, Pisuchpen P, Sujirakul T, Wongchaisuwat N, Apivatthakakul A, Kumaramanickavel G, Leroy B, Michaelides M, Pontikos N, Cheng CY, Pang CP, Chen LJ, Chan HW. Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia- Pacific: A Survey from the APIED Network. Asia Pac J Ophthalmol (Phila). 2024 Sep-Oct;13(5):100098.
  30. Kido A, Miyake M, Watanabe N. Interventions to increase time spent outdoors for preventing incidence and progression of myopia in children. Cochrane Database Syst Rev. 2024 Jun 12;6(6):CD013549.
  31. Akiyama M, Tamiya G, Fujiwara K, Shiga Y, Yokoyama Y, Hashimoto K, Sato M, Sato K, Narita A, Hashimoto S, Ueda E, Furuta Y, Hata J, Miyake M, Ikeda HO, Suda K, Numa S, Mori Y, Morino K, Murakami Y, Shimokawa S, Nakamura S, Yawata N, Fujisawa K, Yamana S, Mori K, Ikeda Y, Miyata K, Mori K, Ogino K, Koyanagi Y, Kamatani Y; Biobank Japan Project; Ninomiya T, Sonoda KH, Nakazawa T; Japan Glaucoma Society Omics Group; Genomic Research Committee of the Japanese Ophthalmological Society. Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals. Ophthalmology. 2024 Nov;131(11):1271-1280. 
  32. Ueno M, Imai K, Tomioka Y, Horiguchi G, Kameda T, Teramukai S, Tsujikawa A, Inatomi T, Sotozono C, Kinoshita S. Comprehensive combined analysis of physician-initiated phase II and III clinical trials on a cultured human corneal endothelial cell product for treating bullous keratopathy. Jpn J Ophthalmol. 2024 Nov;68(6):660-668. 
  33. Shimada A, Suda K, Nakano E, Tagawa M, Miyata M, Kashii S, Hinoda T, Fushimi Y, Kimura K, Nishigori R, Ahn S, Grinstead J, Tsujikawa A. Accuracy of Diagnosing Optic Neuritis Using DANTE T1-SPACE Imaging. Eye Brain. 2024 Oct 29;16:65-73.
  34. Jiang L, Huang L, Dai C, Zheng R, Miyake M, Mori Y, Nakao SY, Morino K, Ymashiro K, Miao YB, Li Q, Ren W, Ye Z, Li H, Yang Z, Shi Y. Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia. Adv Sci (Weinh). 2024 Oct;11(40):e2308968.
  35. Hirano T, Murata T, Nakao S, Shimura M, Nozaki M, Suzuma K, Nagaoka T, Sugimoto M, Takamura Y, Murakami T, Iwasaki K, Tsujimura J, Yoshida S. Optimization of individualized faricimab dosing for patients with diabetic macular edema: Protocol for the SWAN open-label, single-arm clinical trial. PLoS One. 2024 Oct 10;19(10):e0311484.
  36. Nakao SY, Miyata M, Yamamoto A, Kawai K, Suda K, Nakano E, Tagawa M, Tsujikawa A. Differences in the corrective effects of vertical transposition accompanied by recession-resection of the horizontal rectus muscles for complicated vertical deviation. Eye (Lond). 2024 Dec;38(17):3252-3257.
  37. Hata M, Hata M, Dejda A, Pilon F, Diaz-Marin R, Fournier F, Joyal JS, Cagnone G, Ochi Y, Crespo-Garcia S, Wilson AM, Sapieha P. Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2411640121.
  38. Akada M, Muraoka Y, Morooka S, Ishihara K, Hata M, Tsujikawa A. Severe Circulatory Disturbance in Optic Disc, Retina, and Choroid Following Sub-Tenon Triamcinolone Acetonide Injection for Posterior Scleritis. Retin Cases Brief Rep. 2024 Jul 23.
  39. Morino K, Miyake M, Nagasaki M, Kawaguchi T, Numa S, Mori Y, Yasukura S, Akada M, Nakao SY, Nakata A, Hashimoto H, Otokozawa R, Kamoi K, Takahashi H, Tabara Y, Matsuda F, Ohno-Matsui K, Tsujikawa A; Nagahama Study Group. Genome- wide Meta-analysis for Myopic Macular Neovascularization Identified a Novel Susceptibility Locus and Revealed a Shared Genetic Susceptibility with Age- Related Macular Degeneration. Ophthalmol Retina. 2025 Apr;9(4):367-377.
  40. Nishikawa K, Murakami T, Yoshida M, Terada N, Ishihara K, Mori Y, Ito S, Tsujikawa A. Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy. Diabetes. 2025 Mar 1;74(3):409-415.
  41. Asaoka R, Miyata M, Oishi A, Fujino Y, Murata H, Aoki S, Azuma K, Obata R, Inoue T. EFFICIENT ASSESSMENT OF PROGRESSION IN CLINICAL TRIALS IN RETINITIS PIGMENTOSA. Retina. 2025 Apr 1;45(4):765-773.
  42. Yoshida M, Murakami T, Nishikawa K, Ishihara K, Mori Y, Tsujikawa A. Severity Scale of Diabetic Macular Ischemia Based on the Distribution of Capillary Nonperfusion in OCT Angiography. Ophthalmol Sci. 2024 Sep 7;5(1):100603.