RESEARCH RESULTS

研究業績

2020年　教室業績
  1. Yoshitake T, Murakami T, Suzuma K, Dodo Y, Fujimoto M, Tsujikawa A. Hyperreflective Foci in the Outer Retinal Layers as a Predictor of the Functional Efficacy of Ranibizumab for Diabetic Macular Edema. Sci Rep. 2020;10(1):873.
  2. Fan W, Nittala MG, Fleming A, Robertson G, Uji A, Wykoff CC, Brown DM, van Hemert J, Ip M, Wang K, Falavarjani KG, Singer M, Sagong M, Sadda SR. Relationship Between Retinal Fractal Dimension and Nonperfusion in Diabetic Retinopathy on Ultrawide-Field Fluorescein Angiography. Am J Ophthalmol. 2020;209:99-106.
  3. Hou H, Moghimi S, Zangwill LM, Proudfoot JA, Akagi T, Shoji T, Girkin CA, Liebmann JM, Weinreb RN. Association between Rates of Retinal Nerve Fiber Layer Thinning after Intraocular Pressure-Lowering Procedures and Disc Hemorrhage. Ophthalmol Glaucoma. 2020;3(1):7-13.
  4. Akagi T, Fujimoto M, Ikeda HO. Anterior Segment Optical Coherence Tomography Angiography of Iris Neovascularization After Intravitreal Ranibizumab and Panretinal Photocoagulation. JAMA Ophthalmol. 2020;138(2):e190318.
  5. Murakami T. OCT Angiography Image Stack Casts Light on Multifaceted Pathophysiologic Features in Diabetic Microaneurysms. Ophthalmol Retina. 2020;4(2):187-188.
  6. Kogo T, Muraoka Y, Iida Y, Ooto S, Murakami T, Kadomoto S, Iida-Miwa Y, Numa S, Miyake M, Miyata M, Uji A, Tsujikawa A. Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2020;61(2):8.
  7. Ikeda HO, Muraoka Y, Hata M, Sumi E, Ikeda T, Nakagawa T, Abe H, Tada H, Morita S, Kakizuka A, Yoshimura N, Tsujikawa A. Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial. PLoS One. 2020;15(2):e0229068.
  8. Hasegawa T, Ikeda HO, Gotoh N, Iida K, Iwai S, Nakano N, Kakizuka A, Tsujikawa A. Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model. Sci Rep. 2020;10(1):4251.
  9. Fan Q, Pozarickij A, Tan NYQ, Guo X, Verhoeven VJM, Vitart V, Guggenheim JA, Miyake M, Tideman JWL, Khawaja AP, Zhang L, MacGregor S, Höhn R, Chen P, Biino G, Wedenoja J, Saffari SE, Tedja MS, Xie J, Lanca C, Wang YX, Sahebjada S, Mazur J, Mirshahi A, Martin NG, Yazar S, Pennell CE, Yap M, Haarman AEG, Enthoven CA, Polling J; Consortium for Refractive Error and Myopia (CREAM); UK Biobank Eye and Vision Consortium, Hewitt AW, Jaddoe VWV, van Duijn CM, Hayward C, Polasek O, Tai ES, Yoshikatsu H, Hysi PG, Young TL, Tsujikawa A, Wang JJ, Mitchell P, Pfeiffer N, Pärssinen O, Foster PJ, Fossarello M, Yip SP, Williams C, Hammond CJ, Jonas JB, He M, Mackey DA, Wong TY, Klaver CCW, Saw SM, Baird PN, Cheng CY. Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error. Commun Biol. 2020;3(1):433.
  10. Sawai Y, Miyata M, Uji A, Ooto S, Tamura H, Ueda-Arakawa N, Muraoka Y, Miyake M, Takahashi A, Kawashima Y, Kadomoto S, Oritani Y, Kawai K, Yamashiro K, Tsujikawa A. Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image. Sci Rep. 2020;10(1):6172.
  11. Terada N, Murakami T, Uji A, Dodo Y, Mori Y, Tsujikawa A. Hyperreflective Walls in Foveal Cystoid Spaces as a Biomarker of Diabetic Macular Edema Refractory to Anti-VEGF Treatment. Sci Rep. 2020;10(1):7299.
  12. Kadomoto S, Uji A, Muraoka Y, Akagi T, Tsujikawa A. Enhanced Visualization of Retinal Microvasculature in Optical Coherence Tomography Angiography Imaging via Deep Learning. J Clin Med. 2020;9(5):1322.
  13. Ogura Y, Kondo M, Kadonosono K, Shimura M, Kamei M, Tsujikawa A. Correction to: Current practice in the management of branch retinal vein occlusion in Japan: Survey results of retina specialists in Japan. Jpn J Ophthalmol. 2020;64(3):321.
  14. Hasegawa T, Ooto S, Akagi T, Kameda T, Nakanishi H, Ikeda HO, Suda K, Tsujikawa A. Expansion of retinal nerve fiber bundle narrowing in glaucoma: An adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol Case Rep. 2020;19:100732.
  15. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H. Generation of a human induced pluripotent stem cell line, BRCi005-A, derived from a Best disease patient with BEST1 mutations. Stem Cell Res. 2020;45:101782.
  16. Kamata K, Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Yasukawa T, Usui H, Muguruma K, Tsujikawa A, Inoue H. Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration. Stem Cell Res. 2020;45:101787.
  17. Kohno M, Musashi K, Ikeda HO, Horibe T, Matsumoto A, Kawakami K. Oral administration of ferulic acid or ethyl ferulate attenuates retinal damage in sodium iodate-induced retinal degeneration mice. Sci Rep. 2020;10(1):8688.
  18. Uchitomi D, Murakami T, Dodo Y, Yasukura S, Morino K, Uji A, Yoshitake T, Fujimoto M, Tsujikawa A. Disproportion of lamellar capillary non-perfusion in proliferative diabetic retinopathy on optical coherence tomography angiography. Br J Ophthalmol. 2020;104(6):857-862.
  19. Yamashiro K, Hosoda Y, Miyake M, Ooto S, Tsujikawa A. Characteristics of Pachychoroid Diseases and Age-Related Macular Degeneration: Multimodal Imaging and Genetic Backgrounds. J Clin Med. 2020;9(7):E2034.
  20. Morino MU, Akagi T, Miyata M, Tsujikawa A. Removal of a Baerveldt Glaucoma Implant and Fibrous Adhesion for Refractory Mechanical Strabismus. Case Rep Ophthalmol. 2020;11(2):249-255.
  21. Hashimoto H, Hata M, Kashii S, Oishi A, Suda K, Nakano E, Miyata M, Tsujikawa A. Analysis of Retinal Nerve Fibre Thickening in Progressive and Non-progressive Non-arteritic Anterior Ischaemic Optic Neuropathy Using Optical Coherence. Neuroophthalmology. 2020;44(5):307-314.
  22. Fan W, Uji A, Wang K, Falavarjani KG, Wykoff CC, Brown DM, Van Hemert J, Sagong M, Sadda SR, Ip M. SEVERITY OF DIABETIC MACULAR EDEMA CORRELATES WITH RETINAL VASCULAR BED AREA ON ULTRA-WIDE FIELD FLUORESCEIN ANGIOGRAPHY: DAVE Study. Retina. 2020;40(6):1029-1037.
  23. Shibata K, Hamasaki I, Toshima S, Shimizu T, Kono R, Miyata M, Morisawa S, Furuse T, Hasebe S, Ohtsuki H, Morizane Y, Shiraga F. Formulas to Estimate Appropriate Surgical Amounts of Unilateral Recession-Resection in Intermittent Exotropia with Distance-Near Disparity. Acta Med Okayama. 2020;74(3):229-236.
  24. Morisawa S, Hamasaki I, Shibata K, Shimizu T, Kono R, Miyata M, Furuse T, Hasebe S, Ohtsuki H, Morizane Y, Shiraga F. Risk factors for excessive postoperative exo-drift after unilateral lateral rectus muscle recession and medial rectus muscle resection for intermittent exotropia. BMC Ophthalmol. 2020;20(1):216.
  25. Hosoda Y, Miyake M, Meguro A, Tabara Y, Iwai S, Ueda-Arakawa N, Nakano E, Mori Y, Yoshikawa M, Nakanishi H, Khor CC, Saw SM, Yamada R, Matsuda F, Cheng CY, Mizuki N, Tsujikawa A, Yamashiro K; Nagahama Study Group. Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson. Commun Biol. 2020;3(1):410.
  26. Oishi A, Noda K, Birtel J, Miyake M, Sato A, Hasegawa T, Miyata M, Numa S, Charbel Issa P, Tsujikawa A. Effect of smoking on macular function and retinal structure in retinitis pigmentosa. Brain Commun. 2020;2(2): fcaa117.
  27. Fan WY, Fleming A, Robertson G, Uji A, van Hemert J, Singer M, Sagong M, Ip M, Sadda SR. Fractal analysis of retinal vasculature in normal subjects on ultra-wide field fluorescein angiography. Int J Ophthalmol. 2020;13(7):1109-1114.
  28. Uji A, Sadda SR, Muraoka Y, Kadomoto S, Ooto S, Murakami T, Akagi T, Miyata M, Tsujikawa A. Effect of image averaging on optical coherence tomography angiography data in eyes with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2020;258(8):1639-1648.
  29. Kadomoto S, Uji A, Muraoka Y, Tsujikawa A. Ultra-widefield confocal imaging of multiple evanescent white dot syndrome. Am J Ophthalmol Case Rep. 2020;19:100861.
  30. Otsuka Y, Oishi A, Miyata M, Oishi M, Hasegawa T, Numa S, Ikeda HO, Tsujikawa A. Wavelength of light and photophobia in inherited retinal dystrophy. Sci Rep. 2020;10(1):14798.
  31. Fujinami K, Oishi A, Yang L, Arno G, Pontikos N, Yoshitake K, Fujinami-Yokokawa Y, Liu X, Hayashi T, Katagiri S, Mizobuchi K, Mizota A, Shinoda K, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Iwata T, Tsujikawa A, Tsunoda K; Japan Eye Genetics Consortium study group. Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population. Am J Med Genet C Semin Med Genet. 2020;184(3):656-674.
  32. Kido A, Tamura H, Ikeda HO, Miyake M, Hiragi S, Tsujikawa A. Nationwide incidence of central retinal artery occlusion in Japan: an exploratory descriptive study using the National Database of Health Insurance Claims (2011-2015). BMJ Open. 2020;10(9):e041104.
  33. Rim TH, Kawasaki R, Tham YC, Kang SW, Ruamviboonsuk P, Bikbov MM, Miyake M, Hao J, Fletcher A, Sasaki M, Nangia V, Sabanayagam C, Yu M, Fujiwara K, Thapa R, Wong IY, Kayama T, Chen SJ, Kuang TM, Yamashita H, Sundaresan P, Chan JC, van Rens GHMB, Sonoda KH, Wang YX, Panda-Jonas S, Harada S, Kim R, Ganesan S, Raman R, Yamashiro K, Gilmanshin TR, Jenchitr W, Park KH, Gemmy Cheung CM, Wong TY, Wang N, Jonas JB, Chakravarthy U, Cheng CY, Yanagi Y; Asian Eye Epidemiology Consortium. Prevalence and Pattern of Geographic Atrophy in Asia: The Asian Eye Epidemiology Consortium. Ophthalmology 2020, 127(10) : 1371-1381.
  34. Kadomoto S, Uji A, Muraoka Y, Tsujikawa A. High-contrast scleroconjunctival microvasculature via deep learning denoising. Indian J Ophthalmol. 2020;68(10):2251.
  35. Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A. Characteristics of pachychoroid neovasculopathy Sci Rep. 2020;10(1):16248.
  36. Hosoda Y, Miyake M, Yamashiro K, Ooto S, Takahashi A, Oishi A, Miyata M, Uji A, Muraoka Y, Tsujikawa A. Deep phenotype unsupervised machine learning revealed the significance of pachychoroid features in etiology and visual prognosis of age-related macular degeneration. Sci Rep. 2020;10(1):18423.
  37. Kadomoto S, Muraoka Y, Uji A, Tamiya R, Ooto S, Murakami T, Oritani Y, Kawai K, Tsujikawa A. Ultrastructure and hemodynamics of microaneurysms in retinal vein occlusion examined by an offset pinhole adaptive optics scanning light ophthalmoscope. Biomed Opt Express. 2020;11(11):6078-6092.
  38. Yamashiro K, Hosoda Y, Miyake M, Takahashi A, Ooto S, Tsujikawa A. Hypothetical pathogenesis of age-related macular degeneration and pachychoroid diseases derived from their genetic characteristics. Jpn J Ophthalmol. 2020;64(6):555-567.
  39. Nagasato D, Muraoka Y, Osaka R, Iida-Miwa Y, Mitamura Y, Tabuchi H, Kadomoto S, Murakami T, Ooto S, Suzuma K, Tsujikawa A. Factors associated with extremely poor visual outcomes in patients with central retinal vein occlusion. Sci Rep. 2020;10(1):19667.
  40. Osaka R, Muraoka Y, Nakano Y, Takasago Y, Koyama Y, Miyoshi Y, Tsujikawa A, Suzuma K. One-year results of anti-vascular endothelial growth factor therapy combined with triamcinolone acetonide for macular edema associated with branch retinal vein occlusion. Jpn J Ophthalmol. 2020;64(6):605-612.
  41. Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S. A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis. Sci Rep. 2020;10(1):20787.
  42. Numa S, Oishi A, Higasa K, Oishi M, Miyata M, Hasegawa T, Ikeda HO, Otsuka Y, Matsuda F, Tsujikawa A. EYS is a major gene involved in retinitis pigmentosa in Japan: genetic landscapes revealed by stepwise genetic screening. Sci Rep. 2020;10(1):20770.
  43. Meguro A, Yamane T, Takeuchi M, Miyake M, Qiao F, Zhao W, Wang IJ, Mizuki Y, Yamada N, Nomura N, Tsujikawa A, Matsuda F, Hosoda Y, Saw SM, Cheng CY, Tsai TH, Yoshida M, Iijima Y, Teshigawara T, Okada E, Ota M, Inoko H, Mizuki N. Genome-wide association study in Asians identifies novel loci for high myopia and highlights a nervous system role in its pathogenesis. Ophthalmology. 2020;127(12):1612-1624.
  44. Hasegawa T, Ikeda HO, Iwai S, Sasaoka N, Kakizuka A, Tsujikawa A. Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model. Sci Rep. 2020;10(1):21653.
  45. Akagi T, Okamoto Y, Kameda T, Suda K, Nakanishi H, Miyake M, Ikeda HO, Yamada T, Kadomoto S, Uji A, Tsujikawa A. Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study. J Clin Med. 2020;9(12):E4016.
  46. Okamoto Y, Akagi T, Suda K, Kameda T, Miyake M, Ikeda HO, Nakano E, Uji A, Tsujikawa A. Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage. Sci Rep. 2020;10(1):22058.
  47. Yamada M, Hiratsuka Y, Nakano T, Kita Y, Watanabe T, Tamura H, Kawasaki R, Yokoyama T, Takano S. Detection of Glaucoma and Other Vision-Threatening Ocular Diseases in the Population Recruited at Specific Health Checkups in Japan. Clin Epidemiol. 2020;12:1381-1388.