RESEARCH RESULTS

研究業績

2018年 教室業績
  1. Osaka R, Shiragami C, Ono A, Kobayashi M, Takasago Y, Yamashita A, Tsujikawa A. Clinical features of treated and untreated type 1 idiopathic macular telangiectasia without the occurrence of secondary choroidal neovascularization followed for 2 years in japanese patients. Retina. 2018;Suppl 1:S114-S122.
  2. Osaka R, Muraoka Y, Miwa Y, Manabe K, Kobayashi M, Takasago Y, Ooto S, Murakami T, Suzuma K, Iida Y, Tsujikawa A. Anti-vascular endothelial growth factor therapy for macular edema following central retinal vein occlusion: 1 initial injection versus 3 monthly injections. Ophthalmologica. 2018;239(1):27-35.
  3. Uji A, Murakami T, Suzuma K, Yoshitake S, Arichika S, Ghashut R, Fujimoto M, Yoshimura N. Influence of vitrectomy surgery on the integrity of outer retinal layers in diagbetic macular edema. Retina. 2018; 38(1):163-172.
  4. Kawamura T, Sato I, Tamura H, Nakao YM, Kawakami K. Influence of comorbidities on the implementation of the fundus examination in patients with newly diagnosed type 2 diabetes. Jpn J Ophthalmol. 2018;62(1):68-76.
  5. Miyata M, Shibata K, Hamasaki I, Hata M, Muraoka Y, Yoshikawa M, Hasebe S, Ohtsuki H. Predictive factors for corrective effect of inferior rectus recession for congenital superior oblique palsy. Graefes Arch Clin Exp Ophthalmol. 2018;256(2):403-409.
  6. Kadomoto S, Muraoka Y, Ooto S, Miwa Y, Iida Y, Suzuma K, Murakami T, Ghashut R, Tsujikawa A, Yoshimura N. Evaluation of macular ischemia in eyes with branch retinal vein occlusion: An optical coherence tomography angiography study. Retina. 2018;38(2):272-282.
  7. Akagi T, Zangwill LM, Weinreb RN. Re: Akagi et al.: Rates of local retinal nerve fiber layer thinning before and after disc hemorrhage in glaucoma (Ophthalmology. 2017;124:1403-1411). Ophthalmology. 2018; 125(3):e22-e23.
  8. Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN. The association between macula and ONH Optical Coherence Tomography Angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes. J Glaucoma. 2018;27(3):227-232.
  9. Sakai-Bizmark R, Goto R, Hiragi S, Tamura H. Influence of Japan's 2004 postgraduate training on ophthalmologist location choice, supply and distribution. BMC Med Educ. 2018;18(1):49.
  10. Hasegawa T, Ikeda HO, Iwai S, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Kakizuka A, Yoshimura N. Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma. Heliyon. 2018;4(2):e00544.
  11. Hiragi S, Yamada H, Tsukamoto T, Yoshida K, Kondo N, Matsubara T, Yanagita M, Tamura H, Kuroda T. Acetaminophen administration and the risk of acute kidney injury: a self-controlled case series study. Clin Epidemiol. 2018;10:265-276.
  12. Nakanishi H, Suda K, Yoshikawa M, Akagi T, Kameda T, Ikeda HO, Yokota S, Kurimoto Y, Tsujikawa A. Association of Bruch's membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 2018;256(3):599-610.
  13. Kawashima-Kumagai K, Tabara Y, Yamashiro K, Setoh K, Yoshikawa M, Kawaguchi T, Miyake M, Nakanishi H, Muraoka Y, Takahashi Y, Kosugi S, Nakayama T, Yoshimura N, Matsuda F, Tsujikawa A; Nagahama Study group. Association of retinal vessel calibers and longitudinal changes in arterial stiffness: the Nagahama study. J Hypertens. 2018;36(3):587-593.
  14. Tsujikawa A, Akagi-Kurashige Y, Yuzawa M, Ishibashi T, Nakanishi H, Nakatani E, Teramukai S, Fukushima M, Yoshimura N; AMD2000 Study Group. Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report. Jpn J Ophthalmol. 2018; 62(2):127-136.
  15. Akagi-Kurashige Y, Tsujikawa A, Yuzawa M, Ishibashi T, Nakanishi H, Nakatani E, Teramukai S, Fukushima M, Yoshimura N; AMD2000 study group. A 5-year multicenter prospective cohort study on the long-term visual prognosis and predictive factors for visual outcome in Japanese patients with age-related macular degeneration: the AMD2000 study. Jpn J Ophthalmol. 2018;62(2):137-143.
  16. Numa S, Yamashiro K, Wakazono T, Yoshikawa M, Miyake M, Nakanishi H, Oishi A; Nagahama Study Group, Tabara Y, Matsuda F, Yoshimura N, Tsujikawa A. Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population. Sci Rep. 2018;8(1):4594.
  17. Suh MH, Zangwill LM, Manalastas PIC, Belghith A, Yarmohammadi A, Akagi T, Diniz-Filho A, Saunders L, Weinreb RN. Deep-Layer microvasculature dropout by optical coherence tomography angiography and microstructure of parapapillary atrophy. Invest Ophthalmol Vis Sci. 2018;59(5):1995-2004.
  18. Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yamashiro K; Japan Glaucoma Society Omics Group (JGS-OG), Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Aihara M, Araie M, Yamamoto T, Kiuchi Y, Nakamura M, Ikeda Y, Sonoda KH, Ishibashi T, Nitta K, Iwase A, Shirato S, Oka Y, Satoh M, Sasaki M, Fuse N, Suzuki Y, Cheng CY, Khor CC, Baskaran M, Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH, Pasquale LR, Haines JL; NEIGHBORHOOD Consortium, Wiggs JL, Burdon KP, Gharahkhani P, Hewitt AW, Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A, Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T, Kubo M. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum Mol Genet. 2018;27(8):1486-1496.
  19. Hata M, Ikeda HO, Iwai S, Iida Y, Gotoh N, Asaka I, Ikeda K, Isobe Y, Hori A, Nakagawa S, Yamato S, Arita M, Yoshimura N, Tsujikawa A. Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes. Proc Natl Acad Sci U S A. 2018;115(15):3936-3941.
  20. Takahashi A, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A. Pachychoroid geographic atrophy: clinical and genetic characteristics. Ophthalmol Retina. 2018;2(4):295-305.
  21. Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN. Progression of primary open angle glaucoma in diabetic and non-diabetic patients. Am J Ophthalmol. 2018;189:1-9.
  22. Shimazaki T, Hirooka K, Nakano Y, Nitta E, Ukegawa K, Tsujikawa A. Oxygen venular saturation correlates with a functional loss in primary open-angle glaucoma and normal-tension glaucoma patients. Acta Ophthalmol. 2018;96(3):e304-308.
  23. Hosoda Y, Yoshikawa M, Miyake M, Tabara Y, Shimada N, Zhao W, Oishi A, Nakanishi H, Hata M, Akagi T, Ooto S, Nagaoka N, Fang Y; Nagahama Study group, Ohno-Matsui K, Cheng CY, Saw SM, Yamada R, Matsuda F, Tsujikawa A, Yamashiro K. CCDC102B confers risk of low vision and blindness in high myopia. Nat Commun. 2018;9(1):1782.
  24. Muraoka Y, Iida Y, Ikeda HO, Iwai S, Hata M, Iwata T, Nakayama M, Shimozawa N, Katakai Y, Kakizuka A, Yoshimura N, Tsujikawa A. KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration. Heliyon. 2018;4(5):e00624.
  25. Fujimoto M, Uji A, Ogino K, Akagi T, Yoshimura N. Lacrimal canaliculus imaging using optical coherence tomography dacryography. Sci Rep. 2018;8(1):9808.
  26. Penteado RC, Zangwill LM, Daga FB, Saunders LJ, Manalastas PIC, Shoji T, Akagi T, Christopher M, Yarmohammadi A, Moghimi S, Weinreb RN. Optical coherence tomography angiography macular vascular density measurements and the central 10-2 visual field in glaucoma. J Glaucoma. 2018;27(6):481-489.
  27. Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY, Höhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Polašek O, Hayward C, Bencic G, Rudan I, Wilson JF; CREAM Consortium; 23andMe Research Team; UK Biobank Eye and Vision Consortium, Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimäki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP Jr, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Pärssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet. 2018;50(6):834-848.
  28. Hosoda Y, Yoshikawa M, Miyake M, Tabara Y, Ahn J, Woo SJ, Honda S, Sakurada Y, Shiragami C, Nakanishi H, Oishi A, Ooto S, Miki A; Nagahama Study Group, Iida T, Iijima H, Nakamura M, Khor CC, Wong TY,, Song K, Park KH, Yamada R, Matsuda F, Tsujikawa A, Yamashiro K. CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy. Proc Natl Acad Sci U S A. 2018;115(24):6261-6266.
  29. Murakami T, Suzuma K, Dodo Y, Yoshitake T, Yasukura S, Nakanishi H, Fujimoto M, Oishi M, Tsujikawa A. Decorrelation signal of diabetic hyperreflective foci on optical coherence tomography angiography. Sci Rep. 2018;8(1):8798.
  30. Kido A, Uji A, Morooka S, Kuroda Y, Arichika S, Akagi T, Tsujikawa A. Outer plexiform layer elevations as a marker for prior ocular attacks in patients with Behcet's disease. Invest Ophthalmol Vis Sci. 2018;59(7):2828-2832.
  31. Yoshikawa M, Akagi T, Uji A, Nakanishi H, Kameda T, Suda K, Ikeda HO, Tsujikawa A. Pilot study assessing the structural changes in posttrabecular aqueous humor outflow pathway after trabecular meshwork surgery using swept-source optical coherence tomography. PLoS One. 2018;13(6):e0199739.
  32. Helou S, Yamamoto G, Kondoh E, Tamura H, Hiragi S, Sugiyama O, Okamoto K, Nambu M, Kuroda T. Understanding the Roles of EMR Systems in Japanese Antenatal Care Settings. Stud Health Technol Inform. 2018;251:257-260.
  33. Ono A, Hirooka K, Nakano Y, Nitta E, Nishiyama A, Tsujikawa A. Gene expression changes in the retina after systemic administration of aldosterone. Jpn J Ophthalmol. 2018;62(4):499-507.
  34. Akagi T, Saunders LJ, Shoji T, De Moraes CG, Skaat A, Manalastas PIC, Girkin CA, Liebmann JM, Zangwill LM, Weinreb RN. Association between rates of retinal nerve fiber layer thinning and previous disc hemorrhage in glaucoma. Opthalmology Glaucoma. 2018;July–August 1(1):23-31.
  35. Akagi T, Zangwill LM, Shoji T, Suh MH, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN. Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography. PLoS One. 2018;13(8):e0201729.
  36. Inoue S, Kawashima M, Hiratsuka Y, Nakano T, Tamura H, Ono K, Murakami A, Tsubota K, Yamada M. Assessment of physical inactivity and locomotor dysfunction in adults with visual impairment. Sci Rep. 2018;8(1):12032.
  37. Hirose F, Kiryu J, Tabata Y, Tamura H, Musashi K, Takase N, Usui H, Kuwayama S, Kato A, Yoshimura N, Ogura Y, Yasukawa T. Experimental proliferative vitreoretinopathy in rabbits by delivery of bioactive proteins with gelatin microspheres. Eur J Pharm Biopharm. 2018;129:267-272.
  38. Ghashut R, Muraoka Y, Ooto S, Iida Y, Miwa Y, Suzuma K, Murakami T, Kadomoto S, Tsujikawa A, Yoshimura N. Evaluation of macular ischemia in eyes with central retinal vein occlusion: An optical coherence tomography angiography study. Retina. 2018;38(8):1571-1580.
  39. Ono A, Shiragami C, Manabe S, Takasago Y, Osaka R, Kobayashi M, Yamashita A, Tsujikawa A, Hirooka K. One-year outcomes of fixed treatment of intravitreal aflibercept for exudative age-related macular degeneration and the factor of visual prognosis. Medicine. 2018;97(31):e11737.
  40. Miyata M, Oishi A, Tsujikawa A. Swept-Source optical coherence tomography angiography of microaneurysms in myopic retinoschisis. JAMA Ophthalmol. 2018;136(8):e181637.
  41. Kuroda Y, Yamashiro K, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyata M, Hata M, Takahashi A, Wakazono T, Yoshimura N, Tsujikawa A. Macular atrophy and macular morphology in aflibercept-treated neovascular age-related macular degeneration. Retina. 2018;38(9):1743-1750.
  42. Miyata M, Oishi A, Oishi M, Hasegawa T, Ikeda HO, Tsujikawa A. Long-term efficacy and safety of anti-VEGF therapy in retinitis pigmentosa: a case report. BMC Ophthalmol. 2018;18(1):248.
  43. Osaka R, Manabe K, Manabe S, Nakano Y, Takasago Y, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A. Persistent metamorphopsia associated with branch retinal vein occlusion. PLoS One. 2018;13(9):e0204015.
  44. Miyata M, Oishi A, Hasegawa T, Ishihara K, Oishi M, Ogino K, Sugahara M, Hirashima T, Hata M, Yoshikawa M, Tsujikawa A. Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography. Br J Ophthalmol. 2018;102(9):1208-1212.
  45. Kobayashi N, Hirooka K, Nitta E, Ukegawa K, Tsujikawa A. Visual acuity and corneal higher-order aberrations after EX-PRESS or trabeculectomy, and the determination of associated factors that influence visual function. Int Ophthalmol. 2018;38(5):1969-1976.
  46. Miyata M, Oishi A, Ogino K, Oishi M, Hasegawa T, Nagasaku Y, Ikeda HO, Ohtsuki H, Tsujikawa A. Relationship between ocular deviation and visual function in retinitis pigmentosa. Sci Rep. 2018;8(1):14880.
  47. Oishi A, Oishi M, Miyata M, Hirashima T, Hasegawa T, Numa S, Tsujikawa A. Multimodal imaging for differential diagnosis of bietti crystalline dystrophy. Ophthalmol Retina. 2018;2(10):1071-1077.
  48. Miyata M, Yoshikawa M, Ohtsuki H, Muraoka Y, Hata M, Yokota S, Fujimoto M, Miyake M, Tabara Y, Matsuda F, Yoshimura N; Nagahama Study Group. Age-related change and sex difference over 60s in disc-fovea angle in Japanese population: the Nagahama Study. Acta Ophthalmol. 2018;96(7):e840-e845.
  49. Hiragi S, Tamura H, Goto R, Kuroda T. The effect of model selection on cost-effectiveness research: a comparison of kidney function-based microsimulation and disease grade-based microsimulation in chronic kidney disease modeling. BMC Med Inform Decis Mak. 2018;18(1):94.
  50. Numa S, Akagi T, Uji A, Suda K, Nakanishi H, Kameda T, Ikeda HO, Tsujikawa A. Visualization of the lamina cribrosa microvasculature in normal and glaucomatous eyes: a swept-source optical coherence tomography angiography study. J Glaucoma. 2018;27(11):1032-1035.
  51. Kadomoto S, Uji A, Tsujikawa A. Anterior segment optical coherence tomography angiography in a patient with persistent pupillary membrane. JAMA Ophthalmol. 2018;136(11):e182932.
  52. Wakazono T, Yamashiro K, Miyake M, Hata M, Miyata M, Uji A, Nakanishi H, Oishi A, Tamura H, Ooto S, Tsujikawa A. Time-Course change in eye shape and development of staphyloma in highly myopic eyes. Invest Ophthalmol Vis Sci. 2018;59(13):5455-5461.
  53. Suda K, Akagi T, Nakanishi H, Noma H, Ikeda HO, Kameda T, Hasegawa T, Tsujikawa A. Evaluation of structure-function relationships in longitudinal changes of glaucoma using the spectralis OCT follow-up mode. Sci Rep. 2018;8(1):17158.
  54. Suda M, Nakanishi H, Akagi T, Murakami T, Suzuma K, Suda K, Kameda T, Morooka S, Ikeda HO, Tsujikawa A. Baerveldt or Ahmed glaucoma valve implantation with pars plana tube insertion in Japanese eyes with neovascular glaucoma: 1-year outcomes. Clin Ophthalmol. 2018;12:2439-2449.
  55. Hosoda Y, Miyata M, Uji A, Ooto S, Yamashiro K, Tamura H, Oishi A, Ueda-Arakawa N, Miyake M, Hata M, Muraoka Y, Takahashi A, Tsujikawa A. Novel predictors of visual outcome in Anti-VEGF Therapy for myopic choroidal neovascularization derived using OCT Angiography. Ophthalmol Retina. 2018;2(11):1118-1124.
  56. Spaide RF, Ooto S, Curcio CA. Subretinal drusenoid deposits AKA pseudodrusen. Surv Ophthalmol. 2018;63(6):782-815.
  57. Akagi T, Uji A, Huang AS, Weinreb RN, Yamada T, Miyata M, Kameda T, Ikeda HO, Tsujikawa A. Conjunctival and intrascleral vasculatures assessed using anterior-segment optical coherence tomography angiography in normal eyes. Am J Ophthalmol. 2018;196:1-9.
  58. Muraoka Y, Uji A, Ishikura M, Iida Y, Ooto S, Tsujikawa A. Segmentation of the Four-Layered retinal vasculature using high-resolution optical coherence tomography angiography reveals the microcirculation unit. Invest Ophthalmol Vis Sci. 2018;59(15):5847-5853.
  59. Yasukura S, Murakami T, Suzuma K, Yoshitake T, Nakanishi H, Fujimoto M, Oishi M, Tsujikawa A. Diabetic nonperfused areas in macular and extramacular regions on wide-field optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2018;59(15):5893-5903.