RESEARCH RESULTS

研究業績

2017年　教室業績
  1. Hata M, Yamashiro K, Ooto S, Oishi A, Tamura H, Miyata M, Ueda-Arakawa N, Takahashi A, Tsujikawa A, Yoshimura N. Intraocular vascular endothelial growth factor levels in pachychoroid neovasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2017, 58(1) : 292-298.
  2. Arichika S, Uji A, Murakami T, Suzuma K, Gotoh N, Yoshimura N. Correlation of retinal arterial wall thickness with atherosclerosis predictors in type 2 diabetes without clinical retinopathy. Br J Ophthalmol 2017 , 101(1) : 69-74.
  3. Yoshikawa M, Akagi T, Nakanishi H, Ikeda HO, Morooka S, Yamada H, Hasegawa T, Iida Y, Yoshimura N. Longitudinal change in choroidal thickness after trabeculectomy in primary open-angle glaucoma patients. Jpn J Ophthalmol 2017 , 61(1) : 105-112.
  4. Nishida A, Kojima H, Kameda T, Mandai M, Kurimoto Y. Five-year outcomes of pars plana vitrectomy for macular edema associated with branch retinal vein occlusion. Clin Ophthalmol 2017 , 11 : 369-375.
  5. Yarmohammadi A, Zangwill LM, Diniz-Filho A, Saunders LJ, Suh MH, Wu Z, Manalastas PIC, Akagi T, Medeiros FA, Weinreb RN. Peripapillary and macular vessel density in patients with glaucoma and single-hemifield visual field defect. Ophthalmology 2017 , 124(5) : 709-719.
  6. Kobayashi M, Hirooka K, Ono A, Nakano Y, Nishiyama A, Tsujikawa A. The relationship between the renin-angiotensin-aldosterone system and NMDA receptor-mediated signal and the prevention of retinal ganglion cell death. Invest Ophthalmol Vis Sci 2017, 58(3) : 1397-1403.
  7. Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N. Association between retinal hemorrhagic patterns and perfusion status in eyes with acute central retinal vein occlusion. Retina 2017, 37(3) : 500-508.
  8. Hata M, Ikeda HO, Kikkawa C, Iwai S, Muraoka Y, Hasegawa T, Kakizuka A, Yoshimura N. KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep 2017 , 7 : 44873.
  9. Uji A, Abdelfattah NS, Boyer DS, Balasubramanian S, Lei J, Sadda SR. Variability of retinal thickness measurements in tilted or stretched optical coherence tomography images. Transl Vis Sci Technol 2017 , 6(2) : 1.
  10. Shiragami C, Miyake M, Fujiwara A, Morizane Y, Tsujikawa A, Yamashita A, Shiraga F. Effect of topical isopropyl unoprostone on macular atrophy progression in eyes with exudative age-related macular degeneration. Medicine 2017 , 96(12) : e6422.
  11. Miwa Y, Muraoka Y, Osaka R, Ooto S, Murakami T, Suzuma K, Takahashi A, Iida Y, Yoshimura N, Tsujikawa A. Ranibizumab for macular edema after branch retinal vein occlusion: one initial injection versus three monthly injections. Retina 2017, 37(4) : 702-709.
  12. Mori Y, Murakami T, Suzuma K, Ishihara K, Yoshitake S, Fujimoto M, Dodo Y, Yoshitake T, Miwa Y, Tsujikawa A. Relation between macular morphology and treatment frequency during twelve months with ranibizumab for diabetic macular edema. PLoS One 2017,12(4) : e0175809.
  13. Sugahara M, Miyata M, Ishihara K, Gotoh N, Morooka S, Ogino K, Hasegawa T, Hirashima T, Yoshikawa M, Hata M, Muraoka Y, Ooto S, Yamashiro K, Yoshimura N. Optical coherence tomography angiography to estimate retinal blood flow in eyes with retinitis pigmentosa. Sci Rep 2017, 7 : 46396.
  14. Nakano Y, Manabe K, Osaka R, Takasago Y, Ono A, Kobayashi M, Fujita T, Shiragami C, Hirooka K, Tsujikawa A. The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels. Clin Ophthalmol 2017, 11 : 759-765.
  15. Kuroda Y, Uji A, Morooka S, Nishijima K, Yoshimura N. Morphological features in anterior scleral inflammation using swept-source optical coherence tomography with multiple B-scan averaging. Br J Ophthalmol 2017 , 101(4) : 411-417.
  16. Yoshikawa M, Nakanishi H, Yamashiro K, Miyake M, Akagi T, Gotoh N, Ikeda H, Suda K, Yamada H, Hasegawa T, Iida Y, Yamada R, Matsuda F, Yoshimura N; Nagahama Study Group. Association of glaucoma-susceptible genes to regional circumpapillary retinal nerve fiber layer thickness and visual field defects. Invest Ophthalmol Vis Sci 2017 , 58(5) : 2510-2519.
  17. Okubo Y, Masuyama R, Iwanaga A, Koike Y, Kuwatsuka Y, Ogi T, Yamamoto Y, Endo Y, Tamura H, Utani A. Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules. PLoS One 2017 , 12(5) : e0177375.
  18. Hirooka K, Nitta E, Ukegawa K, Tsujikawa A. Vision-related quality of life following glaucoma filtration surgery. BMC Ophthalmol 2017 , 17(1) : 66.
  19. Miyata M, Hata M, Ooto S, Ogino K, Gotoh N, Morooka S, Hasegawa T, Hirashima T, Sugahara M, Kuroda Y, Yamashiro K, Yoshimura N. Choroidal and retinal atrophy of bietti crystalline dystrophy patients with cyp4v2 mutations compared to retinitis pigmentosa patients with eys mutations. Retina 2017, 37(6) : 1193-1202.
  20. Nakayama T, Imanaka Y, Okuno Y, Kato G, Kuroda T, Goto R, Tanaka S, Tamura H, Fukuhara S, Fukuma S, Muto M, Yanagita M, Yamamoto Y; BiDAME: Big Data Analysis. Analysis of the evidence-practice gap to facilitate proper medical care for the elderly: investigation, using databases, of utilization measures for National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB). Environ Health Prev Med 2017 , 22(1) : 51.
  21. Yoshikawa M, Yamashiro K, Nakanishi H, Miyata M, Miyake M, Hosoda Y, Tabara Y, Matsuda F, Yoshimura N; Nagahama Study Group. Association of SIX1/SIX6 locus polymorphisms with regional circumpapillary retinal nerve fibre layer thickness: The Nagahama study. Sci Rep 2017 , 7(1) : 4393.
  22. Uji A, Balasubramanian S, Lei J, Baghdasaryan E, Al-Sheikh M, Sadda SR. Impact of multiple en face image averaging on quantitative assessment from optical coherence tomography angiography images. Ophthalmology 2017 , 124(7) : 944-952.
  23. Hata M, Oishi A, Yamashiro K, Ooto S, Tamura H, Nakanishi H, Ueda-Arakawa N, Akagi-Kurashige Y, Kuroda Y, Takahashi A, Tsujikawa A, Yoshimura N. Incidence and causes of vision loss during aflibercept treatment for neovascular age-related macular degeneration: one-year follow-up. Retina 2017 , 37(7) : 1320-1328.
  24. Iida Y, Akagi T, Nakanishi H, Ohashi Ikeda H, Morooka S, Suda K, Hasegawa T, Yokota S, Yoshikawa M, Uji A, Yoshimura N. Retinal blood flow velocity change in parafoveal capillary after topical tafluprost treatment in eyes with primary open-angle glaucoma. Sci Rep 2017 , 7(1) : 5019.
  25. Fan W, Wang K, Ghasemi Falavarjani K, Sagong M, Uji A, Ip M, Wykoff CC, Brown DM, van Hemert J, Sadda SR. Distribution of nonperfusion area on ultra-widefield fluorescein angiography in eyes with diabetic macular edema: DAVE Study. Am J Ophthalmol 2017 , 180 : 110-116.
  26. Borrelli E, Abdelfattah NS, Uji A, Nittala MG, Boyer DS, Sadda SR. Postreceptor neuronal loss in intermediate age-related macular degeneration. Am J Ophthalmol 2017 , 181 : 1-11.
  27. Hirashima T, Miyata M, Ishihara K, Hasegawa T, Sugahara M, Ogino K, Yoshikawa M, Hata M, Kuroda Y, Muraoka Y, Ooto S, Yoshimura N. Choroidal vasculature in bietti crystalline dystrophy with CYP4V2 mutations and in retinitis pigmentosa with EYS mutations. Invest Ophthalmol Vis Sci 2017, 58(10) : 3871-3878.
  28. Kawashima-Kumagai K, Yamashiro K, Yoshikawa M, Miyake M, Ming GCC, Fan Q, Koh JY, Saito M, Sugahara-Kuroda M, Oishi M, Akagi-Kurashige Y, Nakata I, Nakanishi H, Gotoh N, Oishi A, Tamura H, Ooto S, Tsujikawa A, Kurimoto Y, Sekiryu T, Matsuda F, Khor CC, Cheng CY, Wong TY, Yoshimura N. A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. Sci Rep 2017 , 7(1) : 7173.
  29. Yamashiro K, Mori K, Honda S, Kano M, Yanagi Y, Obana A, Sakurada Y, Sato T, Nagai Y, Hikichi T, Kataoka Y, Hara C, Koyama Y, Koizumi H, Yoshikawa M, Miyake M, Nakata I, Tsuchihashi T, Horie-Inoue K, Matsumiya W, Ogasawara M, Obata R, Yoneyama S, Matsumoto H, Ohnaka M, Kitamei H, Sayanagi K, Ooto S, Tamura H, Oishi A, Kabasawa S, Ueyama K, Miki A, Kondo N, Bessho H, Saito M, Takahashi H, Tan X, Azuma K, Kikushima W, Mukai R, Ohira A, Gomi F, Miyata K, Takahashi K, Kishi S, Iijima H, Sekiryu T, Iida T, Awata T, Inoue S, Yamada R, Matsuda F, Tsujikawa A, Negi A, Yoneya S, Iwata T, Yoshimura N. A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration. Sci Rep 2017 , 7(1) : 9196.
  30. Nitta E, Hirooka K, Shimazaki T, Sato S, Ukegawa K, Nakano Y, Tsujikawa A. Retinal oxygen saturation before and after glaucoma surgery. Acta Ophthalmol 2017 , 95(5) : e350-e353.
  31. Al-Sheikh M, Falavarjani KG, Pfau M, Uji A, Le PP, Sadda SR. Quantitative features of the choriocapillaris in healthy individuals using swept-source optical coherence tomography angiography. Ophthalmic Surg Lasers Imaging Retina 2017 , 48(8) : 623-631.
  32. Hata M, Ikeda HO. Modulation of valosin-containing protein by Kyoto University Substances (KUS) as a novel therapeutic strategy for ischemic neuronal diseases. Neural Regen Res 2017 , 12(8) : 1252-1255.
  33. El Helou S, Karvonen T, Yamamoto G, Kume N, Kobayashi S, Kondo E, Hiragi S, Okamoto K, Tamura H, Kuroda T. Generation of openEHR test datasets for benchmarking. Stud Health Technol Inform 2017 , 245 : 1266.
  34. Morris K, Kume N, Yamamoto G, Kobayashi S, Okamoto K, Tamura H, Kuroda T. Authenticating unknown doctors for access to EHRs based on societal trust. Stud Health Technol Inform 2017 , 245 : 1308.
  35. Akagi T, Zangwill LM, Saunders LJ, Yarmohammadi A, Manalastas PIC, Suh MH, Girkin CA, Liebmann JM, Weinreb RN. Rates of local retinal nerve fiber layer thinning before and after disc hemorrhage in glaucoma. Ophthalmology 2017 , 124(9) : 1403-1411.
  36. Kawashima Y, Hata M, Oishi A, Ooto S, Yamashiro K, Tamura H, Miyata M, Uji A, Ueda-Arakawa N, Tsujikawa A. Association of vascular versus avascular subretinal hyperreflective material with aflibercept response in age-related macular degeneration. Am J Ophthalmol 2017 , 181 : 61-70.
  37. Borrelli E, Uji A, Sarraf D, Sadda SR. Alterations in the choriocapillaris in intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci 2017 , 58(11) : 4792-4798.
  38. Manabe S, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A. Association between parafoveal capillary nonperfusion and macular function in eyes with branch retinal vein occlusion. Retina 2017 , 37(9) : 1731-1737.
  39. Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN. Progressive macula vessel density loss in primary open-angle glaucoma: a longitudinal study. Am J Ophthalmol 2017 , 182 : 107-117.
  40. Iida Y, Muraoka Y, Ooto S, Suzuma K, Murakami T, Iida-Miwa Y, Ghashut R, Tsujikawa A. Morphologic and functional retinal vessel changes in branch retinal vein occlusion: an optical coherence tomography angiography study. Am J Ophthalmol 2017 , 182 : 168-179.
  41. Lei J, Durbin MK, Shi Y, Uji A, Balasubramanian S, Baghdasaryan E, Al-Sheikh M, Sadda SR. Repeatability and reproducibility of superficial macular retinal vessel density measurements using optical coherence tomography angiography en face images. JAMA Ophthalmol 2017 , 135(10) : 1092-1098.
  42. Iida Y, Muraoka Y, Uji A, Ooto S, Murakami T, Suzuma K, Tsujikawa A, Arichika S, Takahashi A, Miwa Y, Yoshimura N. Associations between macular edema and circulatory status in eyes with retinal vein occlusion: an adaptive optics scanning laser ophthalmoscopy study. Retina 2017 , 37(10) : 1896-1904.
  43. Manabe K, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A. Metamorphopsia associated with central retinal vein occlusion. PLoS One 2017 , 12(10) : e0186737.
  44. Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN. Reproducibility of optical coherence tomography angiography macular and optic nerve head vascular density in glaucoma and healthy eyes. J Glaucoma 2017 , 26(10) : 851-859.
  45. Uji A, Balasubramanian S, Lei J, Baghdasaryan E, Al-Sheikh M, Sadda SR. Choriocapillaris imaging using multiple en face optical coherence tomography angiography image averaging. JAMA Ophthalmol 2017 , 135(11) : 1197-1204.
  46. Dodo Y, Murakami T, Suzuma K, Yoshitake S, Yoshitake T, Ishihara K, Fujimoto M, Miwa Y, Tsujikawa A. Diabetic neuroglial changes in the superficial and deep nonperfused areas on optical coherence tomography angiography. Invest Ophthalmol Vis Sci 2017, 58(13) : 5870-5879.
  47. Wakazono T, Yamashiro K, Oishi A, Ooto S, Tamura H, Akagi-Kurashige Y, Hata M, Takahashi A, Tsujikawa A, Yoshimura N. Recurrence of choroidal neovascularization lesion activity after aflibercept treatment for age-related macular degeneration. Retina 2017, 37(11) : 2062-2068.
  48. Hata M, Yamashiro K, Oishi A, Ooto S, Tamura H, Miyata M, Ueda-Arakawa N, Kuroda Y, Takahashi A, Tsujikawa A, Yoshimura N. Retinal pigment epithelial atrophy after anti-vascular endothelial growth factor injections for retinal angiomatous proliferation. Retina 2017 , 37(11) : 2069-2077.
  49. Suda K, Murakami T, Gotoh N, Fukuda R, Hashida Y, Hashida M, Tsujikawa A, Yoshimura N. High-density lipoprotein mutant eye drops for the treatment of posterior eye diseases. J Control Release 2017 , 266 : 301-309.