RESEARCH RESULTS

研究業績

2012年　教室業績
  1. Otani A, Kojima H, Guo C, Oishi A, Yoshimura N. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol. 2012;180:328-336.
  2. Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N. Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab. Am J Ophthalmol. 2012;153:68-80.
  3. Uji A, Hangai M, Ooto S, Takayama K, Arakawa N, Imamura H, Nozato K, Yoshimura N. The source of moving particles in parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 2012;53:171-178.
  4. Ogino K, Murakami T, Tsujikawa A, Miyamoto K, Sakamoto A, Ota M, Yoshimura N. Characteristics of optical coherence tomographic hyperreflective foci in retinal vein occlusion. Retina. 2012;32:77-85.
  5. Hata M, Oishi A, Mandai M, Kurimoto Y. Possible vitreous involvement in a case with rapidly progressing choroidal neovascularization. Indian J Ophthalmol. 2012 ;60:57-58.
  6. Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N. Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. Invest Ophthalmol Vis Sci. 2012;16;53:794-798.
  7. Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N. Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. Invest Ophthalmol Vis Sci. 2012;16;53:794-798.
  8. Takayama K, Ooto S, Hangai M, Arakawa N, Oshima M, Hanebuchi M, Inoue T, Yoshimura N. High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy. PLoS One. 2012;7:e33158.
  9. Uji A. Suprachoroidal gas injection as a complication of pars plana vitrectomy confirmed by computed tomography. Clin Ophthalmol. 2012;6:533-536.
  10. Murakami T, Nishijima K, Akagi T, Uji A, Horii T, Ueda-Arakawa N, Muraoka Y, Yoshimura N. Optical coherence tomographic reflectivity of photoreceptors beneath cystoid spaces in diabetic macular edema. Invest Ophthalmol Vis Sci. 2012;53:1506-1511.
  11. Iwama D, Hangai M, Ooto S, Sakamoto A, Nakanishi H, Fujimura T, Domalpally A, Danis RP, Yoshimura N. Automated assessment of drusen using three-dimensional spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:1576-1583.
  12. Kojima H, Otani A, Ogino K, Nakagawa S, Makiyama Y, Kurimoto M, Guo C, Yoshimura N. Outer retinal circular structures in patients with Bietti crystalline retinopathy. Br J Ophthalmol. 2012;96:390-393.
  13. Kumagai K, Ogino N, Hangai M, Larson E. Percentage of fellow eyes that develop full-thickness macular hole in patients with unilateral macular hole. Arch Ophthalmol. 2012;130:393-394.
  14. Kurashige Y, Tsujikawa A, Murakami T, Miyamoto K, Ogino K, Muraoka Y, Yoshimura N. Changes in visual acuity and foveal photoreceptor integrity in eyes with chronic cystoid macular edema with retinal vein occulusion. Retina. 2012;32:792-798.
  15. Hirota K, Akimoto M, Katsura T. Bilateral acute retinal necrosis after herpetic meningitis. Clin Ophthalmol. 2012;6:551-553.
  16. Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K, Kurimoto Y. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. Am J Ophthalmol. 2012;153:698-704.
  17. Uji A, Murakami T, Nishijima K, Akagi T, Horii T, Arakawa N, Muraoka Y, Ellabban AA, Yoshimura N. Association between hyperreflective foci in the outer retina, status of photoreceptor layer, and visual acuity in diabetic macular edema. Am JOphthalmol. 2012;153:710-717.
  18. Muraoka Y, Ikeda HO, Nakano N, Hangai M, Toda Y, Okamoto-Furuta K, Kohda H, Kondo M, Terasaki H, Kakizuka A, Yoshimura N. Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography. PLoS One. 2012;7:e36135.
  19. Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N. Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes. Invest Ophthalmol Vis Sci. 2012;53:2349-2353.
  20. Ota M, Tsujikawa A, Ojima Y, Miyamoto K, Murakami T, Ogino K, Akagi-Kurashige Y, Muraoka Y, Yoshimura N. Retinal sensitivity after resolution of the macular edema associated with retinal vein occlusion. Graefe’s Arch Clin Exp Ophthalmol. 2012;250:635-644.
  21. Harino S, Bessho K, Kida T. Prospective multicenter study of visual outcomes following three different treatments for macular edema associated with branch retinal vein occlusion: a study by the Japanese BRVO study group. Jpn J Ophthalmol. 2012 ;56:250-261.
  22. Horii T, Murakami T, Nishijima K, Akagi T, Uji A, Arakawa N, Muraoka Y, Yoshimura N. Relationship between fluorescein pooling and optical coherence tomographic reflectivity of cystoid spaces in diabetic macular edema. Ophthalmology. 2012;119:1047-1055.
  23. Akimoto M, Akagi T, Okazaki K, Chihara E. Recurrent macular detachment and retinoschisis associated with intrachoroidal cavitation in a normal eye. Case Rep Ophthalmol. 2012;3:169-174.
  24. Kameda T, Inoue T, Inatani M, Fujimoto T, Honjo M, Kasaoka N, Inoue-Mochita M, Yoshimura N, Tanihara H. The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells. Invest Ophthalmol Vis Sci. 2012;53:3092-3103.
  25. Kumagai K, Ogino N, Furukawa M, Hangai M, Kazama S, Nishigaki S, Larson E. Retinal thickness after vitrectomy and internal limiting membrane peeling for macular hole and epiretinal membrane. Clin Ophthalmol. 2012;6:679-688.
  26. Ellabban AA, Tsujikawa A, Ogino K, Ooto S, Yamashiro K, Oishi A, Yoshimura N. Choroidal thickness after intravitreal ranibizumab injections for choroidal neovascularization. Clin Ophthalmol. 2012;6:837-844.
  27. Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N. Macular choroidal thickness and volume in eyes with angioid streaks measured by swept source optical coherence tomography. Am J Ophthalmol. 2012;153:1133-1143.
  28. Murakami T, Frey T, Lin C, Antonetti DA. Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growthfactor-induced permeability in vivo. Diabetes. 2012;61:1573-1583.
  29. Fan Q, Barathi VA, Cheng CY, Zhou X, Meguro A, Nakata I, Khor CC, Goh LK, Li YJ, Lim W, Ho CE, Hawthorne F, Zheng Y, Chua D, Inoko H, Yamashiro K, Ohno-Matsui K, Matsuo K, Matsuda F, Vithana E, Seielstad M, Mizuki N, Beuerman RW, Tai ES, Yoshimura N, Aung T, Young TL, Wong TY, Teo YY, Saw SM. Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. PLoS Genet. 2012;8:e1002753.
  30. Murakami T, Tsujikawa A, Miyamoto K, Sakamoto A, Ota M, Ogino K, Yoshimura N. Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion. Eye (Lond). 2012;26:771-780.
  31. Jirarattanasopa P, Ooto S, Nakata I, Tsujikawa A, Yamashiro K, Oishi A, Yoshimura N. Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2012;53:3663-3672.
  32. Akagi T, Hangai M, Takayama K, Nonaka A, Ooto S, Yoshimura N. In vivo imaging of lamina cribrosa pores by adaptive optics scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 2012;53:4111-4119.
  33. Yamashiro K, Tomita K, Tsujikawa A,Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N. Factors associated with the response of age-related macular degeneration to intravitreal ranibizumab treatment. Am J Ophthalmol. 2012;154:125-136.
  34. Ooto S, Hangai M, Takayama K, Ueda-Arakawa N, Hanebuchi M, Yoshimura N. Photoreceptor damage and foveal sensitivity in surgically closed macular holes: An adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol. 2012;154:174-186.
  35. Morooka S, Hangai M, Nukada M, Nakano N, Takayama K, Kimura Y, Akagi T, Ikeda HO, Nonaka A, Yoshimura N. Wide 3-dimensional macular ganglion cell complex imaging with spectral-domain optical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci. 2012;53:4805-4812.
  36. Inoue T, Kawaji T, Inatani M, Kameda T, Yoshimura N, Tanihara H. Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor in pseudophakic glaucomatous eyes. J Cataract Refract Surg. 2012;38:1389-1397.
  37. Furukawa H, Arimoto H, Shirai T, Ooto S, Hangai M, Yoshimura N. Oximetry of retinal capillaries by multicomponent analysis. Appl Spectrosc. 2012;66:962-969.
  38. Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N. Relationship between retinal morphological findings and visual function in age-related macular degeneration. Graefe’s Arch Clin Exp Ophthalmol.2012;250:1129-1136.
  39. Jirarattanasopa P, Ooto S, Tsujikawa A, Yamashiro K, Hangai M, Hirata M, Matsumoto A, Yoshimura N. Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy. Ophthalmology. 2012;119:1666-1678.
  40. Ellabban AA, Hangai M, Yamashiro K, Nakagawa S, Tsujikawa A, Yoshimura N.Tomographic fundus features in pseudoxanthoma elasticum: comparison with neovascular age-related macular degeneration in Japanese patients. Eye (Lond). 2012;26:1086-1094.
  41. Kimura Y, Hangai M, Morooka S, Takayama K, Nakano N, Nukada M, Ikeda HO, Akagi T, Yoshimura N. Retinal nerve fiber layer defects in highly myopic eyes with early glaucoma. Invest Ophthalmol Vis Sci. 2012;53:6472-6478.
  42. Hata M, Oishi A, Kurimoto Y. Unique Optical Coherence Tomography Findings in A Case of Macular Retinitis Caused By Subacute Sclerosing Panencephalitis. Retinal Cases & Brief Reports. 2012;6:435-437.
  43. Nakata I, Yamashiro K, Akagi-Kurashige Y, Miyake M, Kumagai K, Tsujikawa A, Liu K, Chen LJ, Liu DT, Lai TY, Sakurada Y, Yoneyama S, Cheng CY, Cackett P, Yeo IY, Tay WT, Cornes BK, Vithana EN, Aung T, Matsuo K, Matsuda F, Wong TY, Iijima H, Pang CP, Yoshimura N. Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. Invest Ophthalmol Vis Sci. 2012;53:6576-6581.
  44. Tamura H, Tsujikawa A, Yamashiro K, Akagi-Kurashige Y, Nakata I, Nakanishi H, Hayashi H, Ooto S, Otani A, Yoshimura N. Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration. Am J Ophthalmol. 2012;154:542-548.
  45. Verhoeven VJ, Hysi PG, Saw SM, Vitart V, Mirshahi A, Guggenheim JA, Cotch MF, Yamashiro K, Baird PN, Mackey DA, Wojciechowski R, Ikram MK, Hewitt AW, Duggal P, Janmahasatian S, Khor CC, Fan Q, Zhou X, Young TL, Tai ES, Goh LK, Li YJ, Aung T, Vithana E, Teo YY, Tay W, Sim X, Rudan I, Hayward C, Wright AF, Polasek O, Campbell H, Wilson JF, Fleck BW, Nakata I, Yoshimura N, Yamada R, Matsuda F, Ohno-Matsui K, Nag A, McMahon G, St Pourcain B, Lu Y, Rahi JS, Cumberland PM, Bhattacharya S, Simpson CL, Atwood LD, Li X, Raffel LJ, Murgia F, Portas L, Despriet DD, van Koolwijk LM, Wolfram C, Lackner KJ, Tönjes A, Mägi R, Lehtimäki T, Kähönen M, Esko T, Metspalu A, Rantanen T, Pärssinen O, Klein BE, Meitinger T, Spector TD, Oostra BA, Smith AV, de Jong PT, Hofman A, Amin N, Karssen LC, Rivadeneira F, Vingerling JR, Eiríksdóttir G, Gudnason V, Döring A, Bettecken T, Uitterlinden AG, Williams C, Zeller T, Castagné R, Oexle K, van Duijn CM, Iyengar SK, Mitchell P, Wang JJ, Höhn R, Pfeiffer N, Bailey-Wilson JE, Stambolian D, Wong TY, Hammond CJ, Klaver CC. Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Hum Genet. 2012;131:1467-1480.
  46. Murakami T, Nishijima K, Akagi T, Uji A, Horii T, Ueda-Arakawa N, Muraoka Y, Yoshimura N. Segmentational analysis of retinal thickness after vitrectomy in diabetic macular edema. Invest Ophthalmol Vis Sci. 2012;53:6668-6674.
  47. Suehira N, Ooto S, Hangai M, Matsumoto K, Tomatsu N, Yuasa T, Yamada K, Yoshimura N. Three-beam spectral-domain optical coherence tomography for retinal imaging. J Biomed Opt. 2012;17:106001.
  48. Murakami T, Tsujikawa A, Miyamoto K, Sakamoto A, Ogino K, Muraoka Y, Kurashige Y, Yoshimura N. Disrupted foveal photoreceptors after combined cystoid spaces and retinal detachment in branch vein occlusion treated with bevacizumab. Retina. 2012;32:1853-1861.
  49. Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N. Retinal structural alterations and macular sensitivity in idiopathic macular telangiectasia type 1. Retina. 2012;32:1973-1980.
  50. Takayama K, Hangai M, Durbin M, Nakano N, Morooka S, Akagi T, Ikeda HO, Yoshimura N. A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:6904-6913.
  51. Guo C, Otani A, Oishi A, Kojima H, Makiyama Y, Nakagawa S, Yoshimura N. Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa. Exp Eye Res. 2012;104:39-47.
  52. Miyake M, Yamashiro K, Nakanishi H, Nakata I, Akagi-Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N. Association of paired box 6 with high myopia in Japanese. Mol Vis.2012;18:2726-2735.
  53. Ellabban AA, Tsujikawa A, Matsumoto A, Yamashiro K, Oishi A, Ooto S, Nakata I, Akagi-Kurashige Y, Miyake M, Yoshimura N. Macular choroidal thickness measured by swept source optical coherence tomography in eyes with inferior posterior staphyloma. Invest Ophthalmol Vis Sci. 2012;53:7735-7745.
  54. Hata M, Hirose F, Oishi A, Hirami Y, Kurimoto Y. Changes in choroidal thickness and optical axial length accompanying intraocular pressure increase. Jpn J Ophthalmol. 2012;56:564-568.
  55. Ueda-Arakawa N, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N. Visual prognosis of eyes with submacular hemorrhage associated with exudative age-related macular degeneration. Jpn J Ophthalmol. 2012;56:589-598.
  56. Yoshitake S, Oh H, Kita M. Endoscope-assisted vitrectomy for retinal detachment in an eye with microcornea. Jpn J Ophthalmol. 2012;56:613-616.
  57. Oishi M, Nakamura H, Hangai M, Oishi A, Otani A, Yoshimura N. Contrast visual acuity in patients with retinitis pigmentosa assessed by a contrast sensitivity tester. Indian J Ophthalmol. 2012;60:545-549.
  58. Hata M, Nakamura T, Sotozono C, Kumagai K, Kinoshita S, Kurimoto Y. Atypical continuous keratitis in a case of rheumatoid arthritis accompanying severe scleritis. Cornea. 2012;31:1493-1496.